Role of oxidative stress in the relationship between periodontitis and systemic diseases

Periodontitis is a common inflammatory disease. It characterized by destruction of the supporting structures teeth and could lead to tooth loss systemic inflammation. Bacteria in inflamed gingival tissue virulence factors are capable entering bloodstream induce response, thus influencing pathological process many diseases, such as cardiovascular diabetes, chronic kidney disease, well liver injury. An increasing body evidence show complex interplay between oxidative stress inflammation disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads stress. Oxidative contributes major cellular components damage, including DNA, proteins, lipids. In this article, focus will be on periodontal relationship inflammation, impact therapy parameters.